GOT1

Across TCGA patient cohorts, GOT1 mutation is significantly associated with the RNA expression of many other genes, with 3,090 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOT1-associated genes across cancer lineages are FAM155A-IT1, TAF9, and RN7SKP261. Each is linked with GOT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GOT1-to-partner and partner-to-GOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM155A-IT1 grouped by GOT1-low versus GOT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT1→partner) and Y-score (partner→GOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FAM155A-IT1 →	+0.306	+3.578	<.001	.001	3	3
UCEC	TAF9 →	+0.744	+2.874	<.001	<.001	3	2
COAD	RN7SKP261 →	+0.399	+4.314	<.001	<.001	3	2
COAD	PINCR →	+0.401	+3.120	<.001	.007	3	2
UCEC	ZNF850 →	+0.513	+2.711	.001	.003	3	2
READ	RNU6-921P →	+0.287	+4.421	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,090 associations by consensus.

FAM155A-IT1 by GOT1 expression — SKCM

Explore this box plot interactively →