GOSR2

Across TCGA patient cohorts, GOSR2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOSR2-associated genes across cancer lineages are INPP4B, PDCD4, and STAT3_pY705. Each is linked with GOSR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOSR2-to-partner and partner-to-GOSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GOSR2-low versus GOSR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOSR2→partner) and Y-score (partner→GOSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.415	-3.308	.014	.010	3	1
UCEC	PDCD4 →	-0.698	-3.321	.004	.010	3	1
UCEC	STAT3_pY705 →	-0.411	-3.169	.002	.018	3	1
UCEC	Tuberin_pT1462 →	+0.385	+2.817	.001	.036	3	1
UCEC	PKC-a_pS657 →	-0.582	-3.160	.003	.019	2	1
UCEC	GATA6 →	-0.275	-3.162	.001	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

INPP4B by GOSR2 expression — UCEC

Explore this box plot interactively →