GOSR2

Across TCGA pan-cancer cohorts, GOSR2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GOSR2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GOSR2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GOSR2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where GOSR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GOSR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.836	<.001	12	view →
KICH	Female	II,III,IV	−1.264	<.001	9	view →
LIHC	Female	II,III,IV	+1.150	<.001	9	view →
THCA	Male	III,IV	−0.685	<.001	9	view →
LUAD	Male	II,III,IV	+0.563	<.001	8	view →
COAD	All	II,III,IV	+0.286	<.001	7	view →
BLCA	Female	III,IV	+0.438	.006	6	view →
CHOL	Male	All	+1.674	<.001	5	view →
LUSC	All	All	+0.299	<.001	5	view →
BRCA	All	All	+0.157	.006	4	view →
ESCA	All	All	+0.743	.001	3	view →
STAD	All	II,III,IV	+0.438	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GOSR2–HNSC

Open the HNSC breakdown →