GORAB-AS1

Across TCGA pan-cancer cohorts, GORAB-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GORAB-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GORAB-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GORAB-AS1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where GORAB-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GORAB-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.398	<.001	11	view →
COAD	Female	II,III,IV	−0.558	<.001	10	view →
BLCA	All	III,IV	+0.307	<.001	9	view →
LUAD	Male	II,III,IV	+0.445	<.001	8	view →
STAD	Male	II,III,IV	+0.283	<.001	8	view →
KICH	Female	II,III,IV	−0.172	<.001	8	view →
BRCA	Female	II,III,IV	+0.505	<.001	6	view →
LUSC	Male	All	+0.408	<.001	5	view →
THCA	All	All	−0.088	<.001	5	view →
CHOL	All	All	+0.822	.001	3	view →
LIHC	All	All	+0.071	.001	2	view →
KIRC	All	All	+0.032	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GORAB-AS1–HNSC

Open the HNSC breakdown →