GON4L

Across TCGA pan-cancer cohorts, GON4L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GON4L data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GON4L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GON4L expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where GON4L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.505	.008	16	view →
LUAD	OS	Tertile	II,III,IV	0.916	0.434	.009	6	view →
CCRCC	OS	Median	II,III,IV	0.325	0.891	.046	2	view →
LSCC	OS	Tertile	All	1.000	0.922	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GON4L–UCEC (DFS)

Open the UCEC breakdown →