GON4L

Across TCGA pan-cancer cohorts, GON4L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GON4L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GON4L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GON4L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where GON4L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GON4L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.919	<.001	12	view →
KIRC	Female	All	+0.607	<.001	10	view →
LIHC	Female	II,III,IV	+1.152	<.001	9	view →
KICH	Female	All	−1.149	<.001	8	view →
LUAD	Male	All	+0.646	<.001	7	view →
BRCA	All	II,III,IV	+0.411	<.001	6	view →
BLCA	All	All	+0.407	.003	6	view →
CHOL	Male	All	+2.468	<.001	5	view →
STAD	All	II,III,IV	+0.709	.001	5	view →
LUSC	All	All	+0.452	<.001	5	view →
ESCA	All	All	+0.489	.031	2	view →
COAD	Male	All	+0.338	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GON4L–HNSC

Open the HNSC breakdown →