GON4L

Across TCGA patient cohorts, GON4L protein abundance is significantly associated with the RNA expression of many other genes, with 3,904 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GON4L-associated genes across cancer lineages are RFC3, GBAP1, and UBQLN4. Each is linked with GON4L in more than 2 cancer types. Because this analysis shows association rather than direction, both GON4L-to-partner and partner-to-GON4L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GON4L versus RFC3 in LSCC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GON4L→partner) and Y-score (partner→GON4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC3 →	+0.632	+0.271	.005	.003	3	3
BRCA	GBAP1 →	+0.523	+0.233	<.001	<.001	3	3
LSCC	UBQLN4 →	+0.712	+0.271	<.001	.002	3	3
LSCC	RPL39P16 →	+0.504	+0.215	.004	<.001	3	3
LSCC	RBL1 →	+0.550	+0.268	.003	.002	3	3
UCEC	PIP5K1A →	+0.620	+0.322	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,904 associations by consensus.

GON4L vs RFC3 — LSCC

Explore this scatter interactively →