GON4L

Across TCGA patient cohorts, GON4L mutation is significantly associated with the RNA expression of many other genes, with 5,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GON4L-associated genes across cancer lineages are SAMD11, LONP1, and OTX1. Each is linked with GON4L in more than 3 cancer types. Because this analysis shows association rather than direction, both GON4L-to-partner and partner-to-GON4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAMD11 grouped by GON4L-low versus GON4L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GON4L→partner) and Y-score (partner→GON4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMD11 →	-0.620	-1.553	.003	.004	3	4
UCEC	LONP1 →	+0.530	+1.534	<.001	<.001	3	4
STAD	OTX1 →	+0.675	+3.207	.008	.009	3	4
STAD	TNFSF9 →	+1.500	+3.459	.001	.005	3	4
COAD	SCNN1B →	-1.096	-2.415	<.001	.003	3	4
KIRC	RN7SL756P →	+0.626	+3.690	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,081 associations by consensus.

SAMD11 by GON4L expression — UCEC

Explore this box plot interactively →