GON4L

Across TCGA patient cohorts, GON4L mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GON4L-associated genes across cancer lineages are Smad3, Caspase-7-cleavedD198, and eIF4E. Each is linked with GON4L in more than 3 cancer types. Because this analysis shows association rather than direction, both GON4L-to-partner and partner-to-GON4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad3 grouped by GON4L-low versus GON4L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GON4L→partner) and Y-score (partner→GON4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad3 →	+0.079	+1.353	.041	.013	3	4
UCEC	Caspase-7-cleavedD198 →	+0.635	+1.774	<.001	<.001	3	4
UCEC	eIF4E →	+0.174	+1.825	.001	<.001	3	3
BRCA	4E-BP1_pT70 →	+0.216	+3.000	.006	.037	3	2
BRCA	Di-Ras3 →	-0.214	-2.993	.022	.037	3	2
UCEC	IGFBP2 →	-0.573	-1.222	<.001	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Smad3 by GON4L expression — UCEC

Explore this box plot interactively →