GON4L

Across TCGA cell cohorts, GON4L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,253 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GON4L-associated GO terms across cancer lineages are Regulation of RNA splicing, Negative regulation of myoblast fusion, and mRNA splice site recognition. Each is linked with GON4L in more than 18 cancer types. Because this analysis shows association rather than direction, both GON4L-to-partner and partner-to-GON4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by GON4L-low versus GON4L-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GON4L→partner) and Y-score (partner→GON4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of RNA splicing →	+0.082	+0.776	<.001	<.001	3	19
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.160	+0.768	.006	.002	3	18
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.179	+1.080	<.001	<.001	3	18
OESOPHAGUS	Positive regulation of DNA recombination →	+0.099	+0.786	<.001	<.001	3	18
SOFT_TISSUE	Regulation of mRNA splicing, via spliceosome →	+0.112	+1.047	<.001	<.001	3	18
STOMACH	Nuclear-transcribed mRNA catabolic process →	+0.061	+0.720	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,253 associations by consensus.

Regulation of RNA splicing by GON4L expression — STOMACH

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