GON4L

Across TCGA cell cohorts, GON4L mutation is significantly associated with the RNA expression of many other genes, with 1,080 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GON4L-associated genes across cancer lineages are ATOH1, DPP10, and MRLN. Each is linked with GON4L in more than 1 cancer types. Because this analysis shows association rather than direction, both GON4L-to-partner and partner-to-GON4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATOH1 grouped by GON4L-low versus GON4L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GON4L→partner) and Y-score (partner→GON4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATOH1 →	+0.042	+2.892	.001	.003	3	2
SKIN	DPP10 →	+0.498	+3.748	.007	.001	3	2
UPPER_AERODIGESTIVE_TRACT	MRLN →	+0.246	+3.584	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	ETV3L →	+0.076	+3.722	<.001	.007	3	2
LARGE_INTESTINE	DDHD1 →	+0.657	+1.628	.001	.007	3	2
LARGE_INTESTINE	CCNE1 →	+0.577	+1.628	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

ATOH1 by GON4L expression — SKIN

Explore this box plot interactively →