GOLT1B

Across TCGA patient cohorts, GOLT1B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLT1B-associated genes across cancer lineages are Akt_pT308, ERK2, and Heregulin. Each is linked with GOLT1B in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLT1B-to-partner and partner-to-GOLT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by GOLT1B-low versus GOLT1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLT1B→partner) and Y-score (partner→GOLT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.703	+3.321	.016	.009	3	2
UCEC	ERK2 →	+0.204	+2.584	.022	.011	3	1
UCEC	Heregulin →	-0.153	-2.321	.007	.034	3	1
UCEC	INPP4B →	-0.475	-3.459	.001	.005	3	1
UCEC	MSH2 →	-0.244	-2.973	.023	.035	3	1
UCEC	PRAS40_pT246 →	+0.247	+1.887	.001	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Akt_pT308 by GOLT1B expression — UCEC

Explore this box plot interactively →