GOLT1B

Across TCGA pan-cancer cohorts, GOLT1B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GOLT1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GOLT1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GOLT1B is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and KIRP are the cancer types where GOLT1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GOLT1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.673	<.001	12	view →
BLCA	Male	All	+1.008	<.001	11	view →
KIRP	All	III,IV	+0.967	<.001	11	view →
KIRC	All	IV	+0.613	<.001	11	view →
LIHC	Male	II,III,IV	+1.305	<.001	9	view →
LUAD	Male	II,III,IV	+1.027	<.001	8	view →
STAD	Female	All	+0.950	<.001	7	view →
BRCA	All	III,IV	+0.610	<.001	6	view →
THCA	Female	All	−0.358	<.001	6	view →
LUSC	Male	II,III,IV	+0.844	<.001	5	view →
READ	Male	All	+1.300	.019	4	view →
COAD	Male	All	+0.657	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GOLT1B–HNSC

Open the HNSC breakdown →