GNS

Across TCGA patient cohorts, GNS RNA expression is significantly associated with the protein abundance of many other proteins, with 17,588 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNS-associated proteins across cancer lineages are PLEK, PLOD1, and PTMA. Each is linked with GNS in more than 3 cancer types. Because this analysis shows association rather than direction, both GNS-to-partner and partner-to-GNS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNS versus PLEK in GBM, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNS→partner) and Y-score (partner→GNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEK →	+0.519	+0.437	<.001	<.001	3	4
GBM	PLOD1 →	+0.536	+0.456	<.001	<.001	3	4
OV	PTMA →	-0.843	-0.921	.006	<.001	3	4
CCRCC	EHBP1_S664 →	+0.653	+0.336	.001	.009	3	4
BRCA	RPL5 →	-0.261	-0.635	<.001	<.001	3	4
BRCA	RPL6 →	-0.360	-0.470	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,588 associations by consensus.

GNS vs PLEK — GBM

Explore this scatter interactively →