GNS

Across TCGA pan-cancer cohorts, GNS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GNS data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GNS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNS expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

MESO, LUSC, and LGG are the cancer types where GNS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.282	0.447	.003	89	view →
LUSC	DFS	Median	II,III,IV	0.521	0.703	<.001	57	view →
LGG	OS	Median	All	0.364	0.560	<.001	50	view →
LIHC	DFS	Tertile	All	0.434	0.622	<.001	40	view →
KICH	OS	Median	II,III,IV	0.603	0.958	.002	32	view →
UVM	DFS	Quartile	III,IV	0.392	0.895	.003	30	view →
BLCA	DFS	Tertile	All	0.184	0.484	.016	26	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
GBM	DFS	Median	All	0.189	0.322	<.001	23	view →
SCLC	OS	Median	II,III,IV	0.978	0.443	.012	16	view →
BRCA	DFS	Median	III,IV	0.920	0.830	.005	16	view →
OV	OS	Median	All	0.810	0.869	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GNS–MESO (DFS)

Open the MESO breakdown →