GNS

Across TCGA patient cohorts, GNS protein abundance is significantly associated with the RNA expression of many other genes, with 9,871 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNS-associated genes across cancer lineages are HR, CTSZ, and CD36. Each is linked with GNS in more than 3 cancer types. Because this analysis shows association rather than direction, both GNS-to-partner and partner-to-GNS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNS versus HR in BRCA, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNS→partner) and Y-score (partner→GNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HR →	-1.527	-0.322	<.001	<.001	3	4
GBM	CTSZ →	+0.966	+0.436	<.001	<.001	3	4
GBM	CD36 →	+0.909	+0.283	<.001	<.001	3	4
CCRCC	CR1 →	+0.882	+0.282	<.001	.001	3	4
GBM	SLC16A10 →	+0.927	+0.294	<.001	.001	3	3
OV	FAM219B →	-0.557	-0.402	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,871 associations by consensus.

GNS vs HR — BRCA

Explore this scatter interactively →