GNS

Across TCGA patient cohorts, GNS mutation is significantly associated with the RNA expression of many other genes, with 1,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNS-associated genes across cancer lineages are ATP5F1AP7, MIR548H2, and RNA5SP294. Each is linked with GNS in more than 1 cancer types. Because this analysis shows association rather than direction, both GNS-to-partner and partner-to-GNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1AP7 grouped by GNS-low versus GNS-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNS→partner) and Y-score (partner→GNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ATP5F1AP7 →	+0.067	+5.112	<.001	.001	3	2
BRCA	MIR548H2 →	+0.411	+7.731	<.001	.009	3	2
COAD	RNA5SP294 →	+0.538	+4.308	.001	.009	3	2
COAD	NANOGP10 →	+0.099	+4.666	.001	.005	3	2
COAD	RNU6-389P →	+0.500	+4.602	<.001	.001	3	2
COAD	MIR4716 →	+0.429	+4.962	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,613 associations by consensus.

ATP5F1AP7 by GNS expression — BLCA

Explore this box plot interactively →