GNS

Across TCGA patient cohorts, GNS mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNS-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and ERK2. Each is linked with GNS in more than 1 cancer types. Because this analysis shows association rather than direction, both GNS-to-partner and partner-to-GNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GNS-low versus GNS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNS→partner) and Y-score (partner→GNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.726	+2.341	.001	.019	3	2
UCEC	4E-BP1 →	+0.328	+3.459	.002	.005	3	2
UCEC	ERK2 →	+0.162	+2.000	.032	.030	3	1
UCEC	JNK2 →	+0.175	+1.584	.024	.036	3	1
UCEC	MEK1 →	+0.560	+4.000	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.402	+1.884	.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by GNS expression — UCEC

Explore this box plot interactively →