GNRHR

Across TCGA patient cohorts, GNRHR protein abundance is significantly associated with the RNA expression of many other genes, with 2,180 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GNRHR-associated genes across cancer lineages are KLHDC3, FAM171A1, and RPS2P28. Each is linked with GNRHR in more than 1 cancer types. Because this analysis shows association rather than direction, both GNRHR-to-partner and partner-to-GNRHR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNRHR versus KLHDC3 in LSCC, with a Pearson correlation of -0.91.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNRHR→partner) and Y-score (partner→GNRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KLHDC3 →	-0.996	-0.629	<.001	.001	3	2
LSCC	FAM171A1 →	-1.650	-0.629	.008	.001	3	2
LSCC	RPS2P28 →	-0.633	-0.523	.008	.001	3	2
GBM	FOXO6-AS1 →	-1.257	-0.648	.006	<.001	3	2
GBM	TOB1-AS1 →	-0.520	-0.661	.001	.002	3	2
GBM	PXN-AS1 →	-0.475	-0.646	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,180 associations by consensus.

GNRHR vs KLHDC3 — LSCC

Explore this scatter interactively →