GNRHR

Across TCGA patient cohorts, GNRHR mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNRHR-associated genes across cancer lineages are ERK2, JNK2, and Bax. Each is linked with GNRHR in more than 2 cancer types. Because this analysis shows association rather than direction, both GNRHR-to-partner and partner-to-GNRHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GNRHR-low versus GNRHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNRHR→partner) and Y-score (partner→GNRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.213	+3.169	.044	.020	3	1
UCEC	JNK2 →	+0.304	+3.169	.005	.020	3	1
UCEC	Bax →	+0.383	+3.009	.003	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+1.007	+3.169	.001	.020	1	3
UCEC	A-Raf_pS299 →	-0.151	-3.169	.021	.020	1	2
UCEC	PCNA →	+0.319	+3.169	.007	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by GNRHR expression — UCEC

Explore this box plot interactively →