GNPTAB

Across TCGA patient cohorts, GNPTAB mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPTAB-associated genes across cancer lineages are 4E-BP1, ATM, and MEK1. Each is linked with GNPTAB in more than 2 cancer types. Because this analysis shows association rather than direction, both GNPTAB-to-partner and partner-to-GNPTAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GNPTAB-low versus GNPTAB-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPTAB→partner) and Y-score (partner→GNPTAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.317	+3.000	.024	.034	3	3
UCEC	ATM →	-0.484	-1.540	<.001	.001	3	3
UCEC	MEK1 →	+0.288	+1.777	.004	.001	3	2
UCEC	Notch1 →	+0.134	+1.235	<.001	.018	3	2
UCEC	p90 RSK →	+0.105	+1.080	.046	.037	3	2
UCEC	TFRC →	+0.342	+1.415	.019	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by GNPTAB expression — STAD

Explore this box plot interactively →