GNPTAB

Across TCGA pan-cancer cohorts, GNPTAB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GNPTAB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GNPTAB RNA is repressed in tumor relative to normal tissue. In most cancer types GNPTAB is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where GNPTAB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNPTAB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.783	<.001	11	view →
KIRC	Male	All	+0.485	<.001	9	view →
KIRP	All	II,III,IV	+0.693	.003	8	view →
HNSC	All	All	+0.548	<.001	8	view →
LIHC	Female	II,III,IV	+1.161	<.001	7	view →
LUAD	Female	III,IV	−0.804	<.001	6	view →
BRCA	All	II,III,IV	+0.305	<.001	6	view →
CHOL	All	All	+2.056	<.001	5	view →
STAD	All	II,III,IV	+0.541	.003	4	view →
READ	All	All	−0.777	<.001	3	view →
PAAD	Female	All	−0.674	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GNPTAB–COAD

Open the COAD breakdown →