GNPTAB

Across TCGA cell cohorts, GNPTAB mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNPTAB-associated genes across cancer lineages are IL3, PTCRA, and SNTG2. Each is linked with GNPTAB in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPTAB-to-partner and partner-to-GNPTAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by GNPTAB-low versus GNPTAB-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPTAB→partner) and Y-score (partner→GNPTAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL3 →	+0.054	+4.369	<.001	.008	3	2
SOFT_TISSUE	PTCRA →	+0.189	+4.635	<.001	.003	3	2
LARGE_INTESTINE	SNTG2 →	+0.105	+2.274	.004	.005	3	2
LARGE_INTESTINE	FOXE3 →	+0.131	+3.237	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GABRA6 →	+0.047	+3.870	<.001	.003	3	2
SOFT_TISSUE	PLA2G2F →	+0.181	+4.222	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

IL3 by GNPTAB expression — SOFT_TISSUE

Explore this box plot interactively →