GNPNAT1

Across TCGA patient cohorts, GNPNAT1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPNAT1-associated genes across cancer lineages are JNK2, JNK_pT183_Y185, and PDCD4. Each is linked with GNPNAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPNAT1-to-partner and partner-to-GNPNAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by GNPNAT1-low versus GNPNAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPNAT1→partner) and Y-score (partner→GNPNAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.346	+2.321	<.001	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.203	-3.169	.016	.019	3	1
UCEC	PDCD4 →	-0.671	-2.321	.004	.035	3	1
UCEC	AMPK_pT172 →	+0.504	+2.335	.014	.020	3	1
UCEC	Rab25 →	-0.515	-3.459	.001	.005	3	1
UCEC	Tuberin →	+0.495	+2.179	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK2 by GNPNAT1 expression — UCEC

Explore this box plot interactively →