GNPNAT1

Across TCGA pan-cancer cohorts, GNPNAT1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GNPNAT1 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GNPNAT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GNPNAT1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LUAD, CESC, and KIRP are the cancer types where GNPNAT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.564	0.774	<.001	121	view →
CESC	DFS	Tertile	All	0.631	0.857	<.001	90	view →
KIRP	DFS	Quartile	All	0.761	0.959	<.001	65	view →
PAAD	OS	Tertile	All	0.255	0.536	.001	47	view →
ACC	DFS	Tertile	All	0.398	0.806	<.001	47	view →
KIRC	DFS	Tertile	All	0.848	0.734	.001	46	view →
SARC	OS	Quartile	All	0.397	0.649	<.001	38	view →
BLCA	DFS	Median	All	0.478	0.690	.002	31	view →
HNSC	DFS	Median	II,III,IV	0.271	0.380	.009	29	view →
READ	DFS	Median	All	0.716	0.343	.015	23	view →
PRAD	DFS	Tertile	All	0.879	0.709	<.001	16	view →
TGCT	DFS	Tertile	All	0.714	0.949	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GNPNAT1–LUAD (OS)

Open the LUAD breakdown →