GNPDA1

Across TCGA patient cohorts, GNPDA1 mutation is significantly associated with the RNA expression of many other genes, with 651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPDA1-associated genes across cancer lineages are LAMTOR1, PRSS53, and ACAD8. Each is linked with GNPDA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPDA1-to-partner and partner-to-GNPDA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMTOR1 grouped by GNPDA1-low versus GNPDA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPDA1→partner) and Y-score (partner→GNPDA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAMTOR1 →	+0.427	+3.470	.008	.003	3	1
UCEC	PRSS53 →	+0.428	+3.534	<.001	.002	3	1
UCEC	ACAD8 →	+0.497	+3.191	.009	.009	3	1
UCEC	GUF1 →	+0.651	+3.470	<.001	.003	3	1
UCEC	FAM168B →	+0.737	+3.470	.002	.003	3	1
UCEC	NEIL2 →	+0.700	+3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 651 associations by consensus.

LAMTOR1 by GNPDA1 expression — UCEC

Explore this box plot interactively →