GNPDA1

Across TCGA pan-cancer cohorts, GNPDA1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GNPDA1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GNPDA1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GNPDA1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

UVM, KICH, and LIHC are the cancer types where GNPDA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.417	0.829	<.001	101	view →
KICH	OS	Tertile	II,III,IV	0.483	1.000	<.001	99	view →
LIHC	DFS	Median	All	0.456	0.623	<.001	71	view →
KIRC	OS	Tertile	All	0.727	0.473	<.001	45	view →
BLCA	OS	Median	IV	0.746	0.328	.001	37	view →
LGG	OS	Median	All	0.752	0.868	<.001	37	view →
READ	DFS	Median	All	0.753	0.423	.001	33	view →
MESO	DFS	Quartile	III,IV	0.149	0.572	.010	24	view →
SCLC	DFS	Tertile	All	0.396	0.687	.014	22	view →
BRCA	OS	Tertile	IV	0.716	0.244	.014	20	view →
KIRP	DFS	Tertile	All	0.833	0.953	.001	20	view →
STAD	DFS	Median	II,III,IV	0.680	0.539	.016	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GNPDA1–UVM (OS)

Open the UVM breakdown →