GNPATP

Across TCGA pan-cancer cohorts, GNPATP RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated GNPATP data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher GNPATP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GNPATP expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, HNSC, and DLBC are the cancer types where GNPATP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.220	0.917	<.001	54	view →
HNSC	OS	Tertile	All	0.674	0.369	.018	45	view →
DLBC	DFS	Tertile	IV	0.120	0.683	.001	36	view →
PAAD	OS	Tertile	All	0.100	0.590	<.001	36	view →
KIRP	OS	Tertile	III,IV	0.188	0.703	.005	21	view →
KIRC	DFS	Tertile	II,III,IV	0.865	0.517	.022	18	view →
LUAD	OS	Tertile	II,III,IV	0.278	0.595	.021	18	view →
MESO	OS	Tertile	II,III,IV	0.310	0.566	.028	18	view →
OV	OS	Tertile	IV	0.323	0.659	.005	18	view →
BLCA	OS	Tertile	IV	0.220	0.607	.003	18	view →
SKCM	DFS	Tertile	II,III,IV	1.000	0.564	.035	9	view →
ESCA	OS	Quartile	III,IV	0.663	0.357	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

GNPATP–UVM (OS)

Open the UVM breakdown →