GNPAT

Across TCGA patient cohorts, GNPAT mutation is significantly associated with the RNA expression of many other genes, with 3,985 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPAT-associated genes across cancer lineages are RN7SL607P, RN7SL261P, and RNU6-886P. Each is linked with GNPAT in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPAT-to-partner and partner-to-GNPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL607P grouped by GNPAT-low versus GNPAT-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPAT→partner) and Y-score (partner→GNPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL607P →	+0.153	+4.575	<.001	.009	3	2
CESC	RN7SL261P →	+0.147	+5.010	.001	.009	3	2
COAD	RNU6-886P →	+0.528	+4.374	<.001	.002	3	2
COAD	LINC02497 →	+0.167	+4.418	<.001	.008	3	2
UCEC	FGF21 →	+0.464	+1.431	<.001	.009	3	2
UCEC	LINC02528 →	+0.322	+2.643	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,985 associations by consensus.

RN7SL607P by GNPAT expression — BRCA

Explore this box plot interactively →