GNMT

Across TCGA patient cohorts, GNMT mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GNMT-associated genes across cancer lineages are OR10H4, RPL31P53, and FAM236D. Each is linked with GNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both GNMT-to-partner and partner-to-GNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H4 grouped by GNMT-low versus GNMT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNMT→partner) and Y-score (partner→GNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR10H4 →	+0.084	+6.080	<.001	.002	3	2
SKCM	RPL31P53 →	+0.153	+6.993	<.001	<.001	3	2
SKCM	FAM236D →	+0.298	+6.199	<.001	.001	3	2
SKCM	PABPC1P12 →	+0.064	+5.224	<.001	.007	3	2
SKCM	RPS21P2 →	+0.188	+5.037	<.001	.009	3	2
UCEC	ZNF90P2 →	+0.117	+2.882	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

OR10H4 by GNMT expression — SKCM

Explore this box plot interactively →