GNMT

Across TCGA pan-cancer cohorts, GNMT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GNMT data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GNMT RNA is associated with better overall survival. In most high-consensus cancer types, elevated GNMT expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, KIRC, and MESO are the cancer types where GNMT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.735	0.589	.001	88	view →
KIRC	DFS	Quartile	All	0.471	0.677	<.001	79	view →
MESO	OS	Median	All	0.493	0.287	<.001	68	view →
CESC	OS	Quartile	All	0.942	0.775	<.001	66	view →
LUAD	OS	Tertile	All	0.761	0.570	<.001	61	view →
ESCA	DFS	Tertile	III,IV	0.297	0.620	.002	44	view →
UCS	OS	Tertile	II,III,IV	0.618	0.190	.008	36	view →
LIHC	DFS	Tertile	All	0.357	0.222	.002	31	view →
THYM	OS	Quartile	II,III,IV	1.000	0.477	.002	26	view →
SKCM	OS	Quartile	All	0.846	0.708	.001	22	view →
KICH	DFS	Quartile	II,III,IV	1.000	0.291	.007	18	view →
KIRP	DFS	Median	II,III,IV	0.510	1.000	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GNMT–HNSC (OS)

Open the HNSC breakdown →