GNMT

Across TCGA cell cohorts, GNMT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,376 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GNMT-associated GO terms across cancer lineages are Aromatic amino acid family catabolic process, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Maternal-to-zygotic transition of gene expression. Each is linked with GNMT in more than 9 cancer types. Because this analysis shows association rather than direction, both GNMT-to-partner and partner-to-GNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aromatic amino acid family catabolic process grouped by GNMT-low versus GNMT-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNMT→partner) and Y-score (partner→GNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Aromatic amino acid family catabolic process →	-0.194	-0.589	.004	<.001	3	10
KIDNEY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.136	+0.339	<.001	<.001	3	9
BONE	Maternal-to-zygotic transition of gene expression →	+0.217	+0.497	.002	.007	3	8
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.198	+0.473	<.001	<.001	3	8
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.062	+0.809	.001	.001	3	7
PANCREAS	Trophectodermal cell differentiation →	+0.085	+0.189	.009	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,376 associations by consensus.

Aromatic amino acid family catabolic process by GNMT expression — BLOOD_Leukemia

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