GNMT

Across TCGA cell cohorts, GNMT mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNMT-associated genes across cancer lineages are MYMX and IRAK3. Each is linked with GNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both GNMT-to-partner and partner-to-GNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYMX grouped by GNMT-low versus GNMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNMT→partner) and Y-score (partner→GNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYMX →	+0.296	+2.841	<.001	.009	3	1
LARGE_INTESTINE	IRAK3 →	+0.565	+3.285	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MYMX by GNMT expression — LARGE_INTESTINE

Explore this box plot interactively →