GNLY

Across TCGA pan-cancer cohorts, GNLY Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GNLY data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GNLY Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNLY expression acts as an unfavorable survival marker.

LUSC, ACC, and LUAD are the cancer types where GNLY Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.147	0.661	.001	21	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LUAD	OS	Median	II,III,IV	0.250	0.709	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GNLY–LUSC (DFS)

Open the LUSC breakdown →