GNLY

Across TCGA pan-cancer cohorts, GNLY RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GNLY’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GNLY RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GNLY is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where GNLY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNLY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.300	<.001	12	view →
KIRC	Male	IV	+2.126	<.001	11	view →
LUAD	All	II,III,IV	−1.431	<.001	8	view →
THCA	All	All	+0.992	<.001	7	view →
KICH	Female	All	+1.328	<.001	6	view →
BRCA	Female	II,III,IV	−0.594	<.001	6	view →
LUSC	All	All	−1.558	<.001	5	view →
STAD	All	II,III,IV	+1.082	.026	3	view →
KIRP	Male	III,IV	+1.077	.026	3	view →
ESCA	All	All	+2.047	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GNLY–HNSC

Open the HNSC breakdown →