GNLY

Across TCGA pan-cancer cohorts, GNLY mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNLY data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GNLY mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNLY expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where GNLY mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.933	0.216	.002	6	view →
HNSC	DFS	Quartile	All	0.853	0.988	.026	4	view →
PDAC	DFS	Quartile	II,III,IV	0.581	0.124	.036	3	view →
UCEC	OS	Quartile	All	0.872	1.000	.046	2	view →
LUAD	DFS	Tertile	All	0.893	0.544	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNLY–LSCC (DFS)

Open the LSCC breakdown →