GNLY

Across TCGA patient cohorts, GNLY protein abundance is significantly associated with the RNA expression of many other genes, with 6,138 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GNLY-associated genes across cancer lineages are KLRC1, CRTAM, and CD274. Each is linked with GNLY in more than 4 cancer types. Because this analysis shows association rather than direction, both GNLY-to-partner and partner-to-GNLY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNLY versus KLRC1 in OV, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNLY→partner) and Y-score (partner→GNLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KLRC1 →	+1.088	+2.308	.006	.006	2	5
BRCA	CRTAM →	+0.930	+0.931	<.001	<.001	3	4
BRCA	CD274 →	+1.681	+1.344	<.001	<.001	3	4
BRCA	CD244 →	+1.082	+1.328	<.001	.001	3	4
BRCA	KLRD1 →	+0.786	+1.225	.001	<.001	3	4
HNSC	WARS1 →	+1.386	+0.962	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,138 associations by consensus.

GNLY vs KLRC1 — OV

Explore this scatter interactively →