GNLY

Across TCGA patient cohorts, GNLY mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNLY-associated genes across cancer lineages are THOP1, SH3GL1, and WWC2-AS1. Each is linked with GNLY in more than 1 cancer types. Because this analysis shows association rather than direction, both GNLY-to-partner and partner-to-GNLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THOP1 grouped by GNLY-low versus GNLY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNLY→partner) and Y-score (partner→GNLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THOP1 →	+0.703	+3.595	<.001	.001	3	2
UCEC	SH3GL1 →	+0.476	+3.202	.003	.009	3	2
SKCM	WWC2-AS1 →	+0.149	+3.408	<.001	.002	3	1
SKCM	NIFKP7 →	+0.031	+3.422	.002	.006	3	1
SKCM	RNU6-1224P →	+0.151	+4.039	<.001	.009	3	1
SKCM	TRIM64DP →	+0.017	+4.212	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

THOP1 by GNLY expression — UCEC

Explore this box plot interactively →