GNLY

Across TCGA patient cohorts, GNLY mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNLY-associated genes across cancer lineages are MEK1, Paxillin, and YB-1. Each is linked with GNLY in more than 1 cancer types. Because this analysis shows association rather than direction, both GNLY-to-partner and partner-to-GNLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GNLY-low versus GNLY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNLY→partner) and Y-score (partner→GNLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.482	+3.321	.011	.010	3	1
UCEC	Paxillin →	+0.326	+3.179	.016	.010	3	1
UCEC	YB-1 →	+0.224	+2.196	.007	.034	3	1
UCEC	ATM →	-0.737	-3.321	.001	.010	3	1
UCEC	Claudin-7 →	-0.652	-3.321	.013	.010	3	1
UCEC	4E-BP1 →	+0.435	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by GNLY expression — UCEC

Explore this box plot interactively →