GNL3L

Across TCGA pan-cancer cohorts, GNL3L mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GNL3L data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GNL3L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNL3L expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where GNL3L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.877	0.187	.008	34	view →
HNSC	DFS	Tertile	III,IV	0.653	0.891	.003	25	view →
LSCC	DFS	Tertile	II,III,IV	0.896	0.548	.006	18	view →
CCRCC	OS	Tertile	IV	0.830	0.198	.024	12	view →
PDAC	DFS	Tertile	All	0.857	0.700	.005	11	view →
UCEC	DFS	Tertile	All	1.000	0.924	.043	2	view →
GBM	OS	Median	All	0.779	0.929	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GNL3L–LUAD (DFS)

Open the LUAD breakdown →