GNL3L

Across TCGA pan-cancer cohorts, GNL3L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GNL3L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GNL3L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GNL3L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, BLCA, and HNSC are the cancer types where GNL3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNL3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.454	<.001	11	view →
BLCA	Female	All	+1.076	<.001	11	view →
HNSC	All	III,IV	+0.851	<.001	11	view →
THCA	Male	II,III,IV	−1.248	<.001	9	view →
STAD	Male	II,III,IV	+1.376	<.001	8	view →
LIHC	All	II,III,IV	+0.982	<.001	8	view →
LUAD	Male	All	+0.870	<.001	7	view →
BRCA	All	II,III,IV	+0.711	<.001	6	view →
CHOL	All	All	+2.163	<.001	5	view →
READ	All	All	+0.896	<.001	5	view →
LUSC	Male	II,III,IV	+0.828	<.001	5	view →
KIRP	Female	II,III,IV	+1.228	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GNL3L–COAD

Open the COAD breakdown →