GNL3L

Across TCGA patient cohorts, GNL3L mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNL3L-associated genes across cancer lineages are ATM, 14-3-3_beta, and EGFR_pY1068. Each is linked with GNL3L in more than 1 cancer types. Because this analysis shows association rather than direction, both GNL3L-to-partner and partner-to-GNL3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GNL3L-low versus GNL3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL3L→partner) and Y-score (partner→GNL3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.416	-1.847	.012	.008	3	2
UCEC	14-3-3_beta →	-0.088	-3.432	.016	.005	3	1
UCEC	EGFR_pY1068 →	-0.197	-2.000	.032	.030	3	1
UCEC	A-Raf_pS299 →	-0.132	-2.115	.002	.017	3	1
UCEC	ERK2 →	+0.150	+1.700	.034	.042	3	1
UCEC	INPP4B →	-0.266	-2.115	.025	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by GNL3L expression — UCEC

Explore this box plot interactively →