GNL3L

Across TCGA cell cohorts, GNL3L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,041 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GNL3L-associated GO terms across cancer lineages are Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA 5'-end processing, and DNA replication initiation. Each is linked with GNL3L in more than 18 cancer types. Because this analysis shows association rather than direction, both GNL3L-to-partner and partner-to-GNL3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by GNL3L-low versus GNL3L-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL3L→partner) and Y-score (partner→GNL3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.143	+1.116	<.001	<.001	3	19
LUNG_NSCLC_LUSC	rRNA 5'-end processing →	+0.143	+1.116	<.001	<.001	3	19
BONE	DNA replication initiation →	+0.229	+1.283	<.001	<.001	3	18
OESOPHAGUS	DNA-templated transcription termination →	+0.103	+1.075	.003	.007	3	18
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.121	+1.398	<.001	<.001	3	18
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.139	+0.719	.001	.005	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,041 associations by consensus.

Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by GNL3L expression — LUNG_NSCLC_LUSC

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