Across TCGA patient cohorts, GNL1 mutation is significantly associated with the RNA expression of many other genes, with 1,414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNL1-associated genes across cancer lineages are RNU6-862P, RN7SL248P, and DFFB. Each is linked with GNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNL1-to-partner and partner-to-GNL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL1→partner) and Y-score (partner→GNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-862P →	+0.427	+5.103	.007	.008	3	2
UCEC	RN7SL248P →	+0.080	+3.606	<.001	.002	3	2
UCEC	DFFB →	+0.549	+3.595	.001	.001	3	2
UCEC	SLC25A33 →	+0.771	+3.491	<.001	.002	3	2
SKCM	RNU6-65P →	+0.132	+4.039	<.001	.009	3	2
SKCM	NANOGNBP2 →	+0.144	+2.872	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,414 associations by consensus.

Exploration

GNL1 survival (RNA) · tumor vs normal (RNA) · all GNL1 data types