GNG8

Across TCGA pan-cancer cohorts, GNG8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GNG8 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GNG8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GNG8 expression acts as an unfavorable survival marker.

BLCA and ESCA are the cancer types where GNG8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.197	0.720	.004	18	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GNG8–BLCA (OS)

Open the BLCA breakdown →