GNG8

Across TCGA pan-cancer cohorts, GNG8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GNG8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GNG8 RNA is repressed in tumor relative to normal tissue. In most cancer types GNG8 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRP are the cancer types where GNG8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNG8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.685	<.001	11	view →
KICH	All	III,IV	−1.334	<.001	10	view →
KIRP	All	All	−0.692	<.001	9	view →
HNSC	Male	III,IV	+0.838	<.001	8	view →
BLCA	Female	All	−0.948	.003	7	view →
BRCA	All	III,IV	+0.549	<.001	6	view →
UCEC	All	All	−0.938	<.001	4	view →
LUAD	All	III,IV	+0.634	.008	4	view →
READ	Female	All	−2.658	<.001	2	view →
CHOL	All	All	+0.918	<.001	2	view →
THCA	All	IV	+1.292	.047	1	view →
LUSC	Male	III,IV	−0.669	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GNG8–COAD

Open the COAD breakdown →