GNG8

Across TCGA patient cohorts, GNG8 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,539 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNG8-associated proteins across cancer lineages are SEPTIN6, PDLIM7, and CACNA2D1. Each is linked with GNG8 in more than 4 cancer types. Because this analysis shows association rather than direction, both GNG8-to-partner and partner-to-GNG8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNG8 versus SEPTIN6 in LSCC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG8→partner) and Y-score (partner→GNG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN6 →	+0.387	+0.413	<.001	<.001	3	5
CCRCC	PDLIM7 →	+0.728	+0.501	<.001	<.001	3	5
GBM	CACNA2D1 →	+0.553	+0.585	<.001	<.001	3	4
LUAD	CLPX →	-0.259	-0.467	.002	.005	3	4
CCRCC	CNN1 →	+1.010	+0.486	<.001	<.001	3	4
COAD	GLIPR2 →	+0.283	+0.476	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,539 associations by consensus.

GNG8 vs SEPTIN6 — LSCC

Explore this scatter interactively →