GNG8

Across TCGA cell cohorts, GNG8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,044 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GNG8-associated GO terms across cancer lineages are Intracellular water homeostasis, COP9 signalosome assembly, and DNA replication-dependent chromatin disassembly. Each is linked with GNG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNG8-to-partner and partner-to-GNG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular water homeostasis grouped by GNG8-low versus GNG8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG8→partner) and Y-score (partner→GNG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Intracellular water homeostasis →	-0.854	-1.695	<.001	<.001	3	3
BONE	COP9 signalosome assembly →	+0.119	+0.381	<.001	.001	3	3
BONE	DNA replication-dependent chromatin disassembly →	+0.132	+0.324	.005	.006	3	3
BONE	Intraciliary retrograde transport →	+0.067	+0.324	.004	.006	3	3
BONE	Copper ion transport →	-0.070	-0.523	.002	<.001	3	3
LUNG_SCLC	Regulation of protein deubiquitination →	+0.072	+1.962	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,044 associations by consensus.

Intracellular water homeostasis by GNG8 expression — LUNG_SCLC

Explore this box plot interactively →