GNG7

Across TCGA patient cohorts, GNG7 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG7-associated genes across cancer lineages are STAT3_pY705, A-Raf_pS299, and JNK2. Each is linked with GNG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG7-to-partner and partner-to-GNG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by GNG7-low versus GNG7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG7→partner) and Y-score (partner→GNG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.234	-1.990	.015	.030	3	2
UCEC	A-Raf_pS299 →	-0.125	-1.502	.004	.030	3	1
UCEC	JNK2 →	+0.237	+2.348	.001	.018	3	1
UCEC	MEK1 →	+0.356	+1.502	.007	.030	3	1
UCEC	MSH6 →	-0.320	-2.115	.008	.016	3	1
UCEC	NF2 →	+0.198	+1.502	.012	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

STAT3_pY705 by GNG7 expression — UCEC

Explore this box plot interactively →