GNG7

Across TCGA pan-cancer cohorts, GNG7 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GNG7’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GNG7 RNA is repressed in tumor relative to normal tissue. In most cancer types GNG7 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KIRC are the cancer types where GNG7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNG7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.302	<.001	12	view →
COAD	Female	III,IV	−2.362	<.001	12	view →
KIRC	Male	II,III,IV	−1.529	<.001	12	view →
STAD	Female	All	−1.501	<.001	11	view →
LUAD	Male	II,III,IV	−1.227	<.001	11	view →
THCA	Male	III,IV	−1.167	<.001	11	view →
HNSC	Male	All	−1.309	<.001	10	view →
KIRP	Male	III,IV	−1.713	<.001	9	view →
LUSC	Female	All	−1.916	<.001	8	view →
READ	All	All	−2.000	<.001	7	view →
KICH	All	All	−1.005	<.001	7	view →
UCEC	All	III,IV	−3.000	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GNG7–BLCA

Open the BLCA breakdown →